Synthesis of vinyl sulfides by copper-catalyzed decarboxylative C-S cross-coupling.
نویسندگان
چکیده
A novel method for the synthesis of vinyl sulfides by the decarboxylative cross-coupling of arylpropiolic acids with thiols using copper(I) salts as catalysts has been developed. In the presence of CuI and Cs(2)CO(3), a variety of thiols reacted with arylpropiolic acids to afford the corresponding vinyl sulfides in good to excellent yields with high stereoselectivity for Z-isomers.
منابع مشابه
Synthesis of aryl sulfides by decarboxylative C-S cross-couplings.
Without the need for organohalide precursors, the convenient and general synthesis of aryl (or diaryl) sulfides can be achieved by using aryl carboxylic acids and thiols or disulfides for decarboxylative C-S cross-coupling catalyzed by a bimetallic system (see scheme).
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ورودعنوان ژورنال:
- Organic letters
دوره 12 18 شماره
صفحات -
تاریخ انتشار 2010